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By Robert S. Marks, Christopher R. Lowe, David C. Cullen, Howard H. Weetall, Isao Karube

With contributions from specialists within the box, the guide of Biosensors and Biochips offers a vital reference, underpinning a few of the purposes utilized in clinical diagnostics, environmental regulate and pharmaceutical and nutrients industries. It provides a useful addition for these in either academia and undefined.

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Kutter, Recent developments in detection for microfluidic systems. Electrophoresis, 2004, 25, 3498–3512. 37. M. A. Schwarz and P. C. Hauser, Recent developments in detection methods for microfabricated analytical devices. Lab on a Chip, 2001, 1, 1–6. 38. K. Swinney and D. J. Bornhop, Detection in capillary electrophoresis. Electrophoresis, 2000, 21, 1239–1250. 39. T. Vilkner, D. Janasek, and A. Manz, Micro total analysis systems. Recent developments. Analytical Chemistry, 2004, 76, 3373–3386. 40.

C. G. Zoski, Ultramicroelectrodes: design, fabrication and characterisation. Electroanalysis, 2002, 14, 1041–1051. 41. X. Xie, D. Stueben, and Z. Berner, The application of microelectrodes for the measurements of trace metals in water. Analytical Letters, 2005, 38, 2281–2300. 42. A. C. Barton, S. D. Collyer, F. Davis, D. D. Gornall, K. A. Law, E. C. D. Lawrence, D. W. Mills, S. Myler, J. A. Pritchard, M. Thompson, and S. P. J. Higson, Sonochemically fabricated microelectrode arrays for biosensors offering widespread applicability: Part I.

However, there were numerous production problems, which took many years to overcome, and these resulted in devices that were simply too expensive for most applications. 16 2 THE INVENTIVE SEVENTIES The mid to late 1970s witnessed an explosion of biosensor concepts. It was quickly realized that there were an enormous number of combinations of transducers (Table 2) and bioreceptors. During this time, many of these combinations were tested, initially with enzymes and then with other biological components.

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