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Additional info for Biochemistry & Genetics: Pretest Self-Assessment & Review
The molecular basis of the disease appears to be a. b. c. d. e. Rapid water loss caused by defects in the cell membrane permeability The inactivation of temperature-sensitive transport enzymes in sunlight The induction of a virulent provirus on ultraviolet exposure The inability of the cells to synthesize carotenoid-type compounds A defect in an excision-repair system that removes thymine dimers from DNA 21. Which of the following statements describes both the spiral structure of double-stranded DNA and the spiral structure found in certain segments of protein?
Methionyl–transfer (t) RNA is used for initiation of protein synthesis by which of the following? a. b. c. d. e. Chloroplast ribosomes Eukaryotic mitochondrial ribosomes Eukaryotic cytoplasmic ribosomes Bacterial ribosomes Bacterial cytoplasm 69. Which of the following is required for certain types of eukaryotic protein synthesis but not for prokaryotic protein synthesis? a. b. c. d. e. qxd 11/14/01 10:37 AM Page 47 Gene Expression 47 70. An older man with severe emphysema is found to have decreased amounts and abnormal mobility of α1 antitrypsin (AAT) protein in his serum when analyzed by serum protein electrophoresis.
The DNA sequence changes may alter restriction sites [producing restriction fragment length polymorphisms (RFLPs)], change the numbers of repeated segments [producing variable numbers of tandem repeats (VNTRs)], or alter the genetic code (producing variant proteins, or protein polymorphisms). a. linkage disequilibrium, as with certain HLA alleles and diabetes mellitus). Different mutant alleles may cause indistinguishable phenotypes (allelic heterogeneity), as may mutations at different loci (genetic heterogeneity).